Running Title: Bioenergetics and Insulin Secretion in Mouse, Rat and Human Pancreatic Islets
نویسندگان
چکیده
Department of Biochemistry and Biophysics and Institute for Diabetes, Obesity and Metabolism, 8 University of Pennsylvania School of Medicine, Pennsylvania 19104 9 Department of Surgery, University of Pennsylvania School of Medicine, Pennsylvania 19104 10 Division of Endocrinology, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104 11 Department of Metabolic Diseases, Roche Research Center, Nutley, NJ 07110 12
منابع مشابه
Salvianolic acid B improves insulin secretion from interleukin 1β-treated rat pancreatic islets: The role of PI3K-Akt signaling
Background and Objective: Oxidative stress induced by proinflammatory cytokines such as IL-1β plays a major role in β-cell destruction in diabetes type 1. Salvianolic acid B (Sal B) is a polyphenolic compound with antioxidant and protective effects. Thus, objective of this study was to assess the protection exerted by Sal B on isolated rat islets exposed to IL-1β and to investigate an underlyin...
متن کاملبررسی اثر گلوکزآمین بر فعالیت آنزیم‌های گلوکوکیناز و هگزوکیناز پانکراس و ارتباط آن با ترشح انسولین از جزایر لانگرهانس موش‌های صحرایی سالم و دیابتی نوع 2
Background: Glucokinase serves as a glucose sensor in pancreatic β-cells and plays a key role in glucose homeostasis and glucose-stimulated insulin secretion (GSIS). In the present study we examined the effect of glucosamine, a glucokinase inhibitor, on the pancreatic glucokinase and hexokinase activities and on insulin secretion from freshly rat pancreatic islets of Langerhans. Insulin concen...
متن کاملEffect of Ganoderma lucidum hydroalcoholic extract on insulin release in rat-isolated pancreatic islets
Objective: Ganoderma Lucidum (G. Lucidum) has been suggested to increase serum insulin level.This study was undertaken to investigateits direct effect on the islets of Langerhans. Material and Methods: Male albino Wistar rats were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. The islets were incubated for 60 min in Krebs bicarbonate buffer containi...
متن کاملThe effect of ghrelin on Kiss-1 and KissR gene transcription and insulin secretion in rat islets of Langerhans and CRI-D2 cell line
Objective(s): Ghrelin is a peptide hormone that has been shown to have numerous central and peripheral effects. The central effects including GH secretion, food intake, and energy homeostasis are partly mediated by Kiss1- KissR signaling pathway. Ghrelin and its receptor are also expressed in the pancreatic islets. Ghrelin is one of the key metabolic factors controlling insulin secretion from t...
متن کاملبررسی اثر گلی‌بن‌کلامید بر ترشح انسولین و فعالیت گلوکوکیناز در جزایر لانگرهانس پانکراس موش‌های صحرایی سالم و دیابتی
Background: Sulfonylurea agents such as Glibenclamide (Glyburide) have been widely prescribe in treatment of type 2 diabetic patients for decades, but controversy remains about their precise mechanism of action. On the other hand, glucokinase serves as a glucose sensor in pancreatic β-cells and plays a key role in the regulation of insulin secretion and glucose homeostasis. The aim of the pres...
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تاریخ انتشار 2011